IONS Ionis Pharmaceuticals Inc

$78.97

*Only the 1D chart reflects 15-min delayed quotes during market hours. Other timeframes update after market close.

Reporting for fiscal period ending
Expected on
Report Time: Unknown Release Time
The Whisper Number
Consensus Estimate:
Revenue Estimate:

Latest Earnings Insight

Updated On 1/6/2026

About Ionis Pharmaceuticals Inc

Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapies in the United States. The company is headquartered in Carlsbad, California.

Website: https://www.ionis.com

Sector
LIFE SCIENCES
Industry
PHARMACEUTICAL PREPARATIONS
Exchange
NASDAQ
Country
USA
Currency
USD
Fiscal Year End
December
CIK
874015
Address
2855 GAZELLE COURT, CARLSBAD, CA, US
Valuation
Market Cap
$4.51B
P/E Ratio
nan
PEG Ratio
25.70
Price to Book
7.67
Performance
EPS
$-3.04
Dividend Yield
Profit Margin
-64.40%
ROE
-93.10%
Technicals
50D MA
$31.15
200D MA
$38.24
52W High
$52.34
52W Low
$23.95
Fundamentals
Shares Outstanding
159M
Target Price
$57.39
Beta
0.29

IONS EPS Estimates vs Actual

Estimated
Actual

IONS News & Sentiment

Dec 29, 2025 • 富途牛牛 SOMEWHAT-BEARISH
Revenues Not Telling The Story For Ionis Pharmaceuticals, Inc. (NASDAQ:IONS)
Ionis Pharmaceuticals Inc.'s Price-to-Sales (P/S) ratio of 13.4x is currently in line with the Biotech industry median, despite the company's recent revenue growth being less than most peers and its future revenue forecast being weaker. Analysts predict 20% annual revenue growth for Ionis over the next three years, significantly below the industry's projected 120% growth. This discrepancy suggests investors might be overvaluing the stock, potentially leading to future disappointment if the P/S ratio adjusts to better reflect its growth outlook.
Dec 28, 2025 • MarketBeat NEUTRAL
162,800 Shares in Ionis Pharmaceuticals, Inc. $IONS Bought by Capricorn Fund Managers Ltd
Capricorn Fund Managers Ltd acquired a new position of 162,800 shares in Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) during the third quarter, representing a significant portion of its investment portfolio. Despite insider selling totaling approximately $35.7 million, analysts maintain a "Moderate Buy" rating with a consensus target price of $86.19 for IONS. Ionis Pharmaceuticals, a biotechnology company focused on RNA-targeted therapies, exceeded earnings estimates in its last report.
Dec 24, 2025 • MarketBeat BULLISH
Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) Given Consensus Rating of "Moderate Buy" by Brokerages
Ionis Pharmaceuticals (NASDAQ:IONS) has received a "Moderate Buy" consensus rating from 22 analysts, with an average one-year target price of $86.19. The company's stock shows strong performance, trading near recent highs with a market cap of $13.0 billion, and has seen several recent price-target upgrades. Despite beating Q3 EPS and revenue estimates, Ionis remains unprofitable, while institutional investors hold a significant stake and insiders have recently sold shares.
Dec 20, 2025 • MarketBeat SOMEWHAT-BULLISH
Assenagon Asset Management S.A. Boosts Stock Position in Ionis Pharmaceuticals, Inc. $IONS
Assenagon Asset Management S.A. dramatically increased its stake in Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) by 1,669% in the third quarter, acquiring 294,643 additional shares to hold a total of 312,297 shares valued at approximately $20.43 million. Despite this significant institutional buying, company insiders sold off a substantial amount of stock, totaling about 504,866 shares worth roughly $35.7 million during the last quarter. Wall Street analysts maintain a "Moderate Buy" consensus rating for Ionis, with an average price target of $86.19, and several firms have raised their price objectives and issued positive ratings.
Dec 18, 2025 • Nasdaq BULLISH
RBC Capital Maintains Ionis Pharmaceuticals (IONS) Outperform Recommendation
RBC Capital has reaffirmed its Outperform recommendation for Ionis Pharmaceuticals (IONS). The average one-year price target is $85.60, suggesting an 11.06% upside from its current price, with projected annual revenue of $990MM, a 2.38% increase. Funds and institutions show a bullish outlook with a put/call ratio of 0.57 and several major holders increasing their portfolio allocations in IONS.
Dec 17, 2025 • GuruFocus BULLISH
RBC Capital Raises Price Target for Ionis Pharmaceuticals (IONS) to $95 | IONS Stock News
RBC Capital has maintained its 'Outperform' rating on Ionis Pharmaceuticals (IONS) and significantly increased its price target from $82 to $95, reflecting strong confidence in the company's future. This move aligns with a trend of consistent price target raises from various analysts, signaling positive sentiment and growth potential for the leading developer of antisense technology. Ionis Pharmaceuticals has brought several novel drugs to market and has an average analyst target price of $84.42, implying an upside from its current price.
Sentiment Snapshot

Average Sentiment Score:

0.190
50 articles with scored sentiment

Overall Sentiment:

Bullish

IONS Reported Earnings

Jul 30, 2025
Jun 30, 2025 (Pre market)
0.94 Surprise
  • Reported EPS: $0.70
  • Estimate: $-0.24
  • Whisper:
  • Surprise %: 391.7%
Apr 30, 2025
Mar 31, 2025 (Pre market)
0.09 Surprise
  • Reported EPS: $-0.92
  • Estimate: $-1.01
  • Whisper:
  • Surprise %: 8.5%
Feb 19, 2025
Dec 31, 2024 (Pre market)
0.41 Surprise
  • Reported EPS: $-0.43
  • Estimate: $-0.84
  • Whisper:
  • Surprise %: 49.0%
Nov 06, 2024
Sep 30, 2024 (Pre market)
0.21 Surprise
  • Reported EPS: $-0.95
  • Estimate: $-1.16
  • Whisper:
  • Surprise %: 18.1%
Aug 01, 2024
Jun 30, 2024 (Pre market)
0.47 Surprise
  • Reported EPS: $-0.45
  • Estimate: $-0.92
  • Whisper:
  • Surprise %: 51.1%
May 07, 2024
Mar 31, 2024 (Pre market)
0.07 Surprise
  • Reported EPS: $-0.98
  • Estimate: $-1.05
  • Whisper:
  • Surprise %: 6.7%
Feb 21, 2024
Dec 31, 2023 (Pre market)
0.77 Surprise
  • Reported EPS: $-0.06
  • Estimate: $-0.83
  • Whisper:
  • Surprise %: 92.8%
Nov 02, 2023
Sep 30, 2023 (Pre market)
0.01 Surprise
  • Reported EPS: $-1.03
  • Estimate: $-1.04
  • Whisper:
  • Surprise %: 1.0%
Aug 09, 2023
Jun 30, 2023 (Pre market)
0.3 Surprise
  • Reported EPS: $-0.60
  • Estimate: $-0.90
  • Whisper:
  • Surprise %: 33.3%

Financials